This guide contain Osteoporosis Medications and Oral Health. As we age, our bones begin to lose density and strength, especially after age 50 years. Many factors affect bone density, including diet, physical activity, family history, hormones, lifestyle and certain conditions and medications. Osteoporosis, or porous bone, is a disease that weakens bones and makes them more apt to break. The disease affects about 10 million Americans and causes more than 2 million fractures each year. Another 34 million Americans have low bone density and are at risk of developing osteoporosis. The National Osteoporosis Foundation estimates that one in two women and one in four men older than 50 years are at risk of breaking a bone as a result of osteoporosis.